Biomedical Abnormalities List

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"There are now over 4,000 published studies that show underlying biological abnormalities in patients with this illness. It's not an illness that people can simply imagine that they have and it's not a psychological illness. In my view, that debate, which was waged for 20 years, should now be over"
Dr. Anthony Komaroff, 'Chronic Fatigue Syndrome: Building Credible Momentum in Science & Research' (HHS Website, Page 1, 3 November 2006) [1]


This list is not comprehensive, and only provides a sampling of the 4000 biomedical papers on ME/CFS.


Contents


Biochemical

Oxidative stress

  • Kennedy et al.
'Increased plasma isoprostanes and other markers of oxidative stress in chronic fatigue syndrome' (J Thrombosis and Haemostasis, Volume 1, Supplement1, 12-18 July 2003)
  • Vecchiet et al., 2003.

Dysregulation of anti-viral pathways

  • De Meirleir et al.
'A 37 kDa 2-5A binding protein as a potential biochemical marker for chronic fatigue syndrome' (Am J Med, February 2000)
  • Tiev et al.
'RNase L levels in peripheral blood mononuclear cells: 37-kilodalton/83-kilodalton isoform ratio is a potential test for chronic fatigue syndrome' (Clin Diagn Lab Immunol., March 2003)

Bone

  • Hoskin et al.
'Bone Density and Body Composition in Young Women with Chronic Fatigue Syndrome' (Ann N Y Acad Sci. May, 2000) [2]

Brain

Metabolic abnormalities

  • Puri et al.
'Relative increase in choline in the occipital cortex in chronic fatigue syndrome' (Acta Psychiatr Scand, September 2002)
  • Chaudhuri et al.
'Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome' (Neuroreport, February 2003)

Gene Research

Muscle

Altered metabolism

  • Fulle et al.
'Modification of the functional capacity of sarcoplasmic reticulum membranes in patients suffering from chronic fatigue syndrome' (Neuromuscul Disord., August 2003)
  • Vecchiet et al., 2003.


Enteroviral sequences in muscle

  • Lane et al.
'Enterovirus related metabolic myopathy: a postviral fatigue syndrome.' (J Neurol Neurosurg Psychiatry, October 2003)
  • Douche-Aourik et al.
'Detection of enterovirus in human skeletal muscle from patients with chronic inflammatory muscle disease or fibromyalgia and healthy subjects.' (J Med Virol., December 2003)

Abnormal response to exercise

  • Van Ness et al.

'Subclassifying Chronic Fatigue Syndrome through Exercise Testing' Medicine & Science in Sports & Exercise, June 2003


  • Paul et al.
'Demonstration of delayed recovery from fatiguing exercise in CFS' (Eur J Neurol., 1999)
  • McCully et al.
'Muscle metabolism with blood flow restriction in chronic fatigue syndrome' (J Appl Physiol., March 2004)

Vascular

Endothelial dysregulation

  • Spence et al.
'Enhanced sensitivity of the peripheral cholinergic vascular response' (Am J Med. 15 June 2000)
  • Khan et al.
'Peripheral cholinergic function in humans with chronic fatigue syndrome, Gulf War syndrome and with illness following organophosphate exposure' (Clin Sci (Lond) February, 2004)


Altered brain perfusion

  • Costa et al.
'Brainstem perfusion is impaired in chronic fatigue syndrome' (QJM, November 1995)
  • Tirelli et al.
'Brain positron emission tomography (PET) in chronic fatigue syndrome: preliminary data' (Am J Med, 1998)


Orthostatic hypotension

  • Naschitz et al.
'Hemodynamics instability score in chronic fatigue syndrome and in non-chronic fatigue syndrome' (Semin Arthritis Rheum., December 2002)
  • Stewart et al., 20003.


White blood cells

  • Kennedy et al.
'Biochemical and vascular aspects of pediatric chronic fatigue syndrome' (Archives of Pediatrics and Adolescent Medicine, 9 September 2010)
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