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Project Start Date: 30-SEP-2011 Project End Date: 31-JUL-2016 The global AIDS pandemic continues to expand despite significant advances in understanding HIV-1 pathogenesis and the development of powerful antiviral drugs. HIV-1 is transmitted primarily through sexual contact and more than 30 million people are currently infected worldwide. In some regions of the world such as southern Africa the prevalence of HIV-1 infection exceeds 20%. The devastating spread of HIV-1 in young women in these countries appears out of proportion to the overall risk of infection. Thus it is possible that a biological co-factor contributes to virus spread. The hypothesis of this proposal is that acquisition by HIV- 1 of the envelope glycoprotein of gammaretroviruses (murine leukemia virus-related viruses) in a process we call ""natural pseudotyping"" expands the cellular tropism of HIV-1 enabling it to directly infect vaginal epithelial cells thereby dramatically increasing the risk of infection during sexual intercourse. We propose a molecular epidemiology study consisting of four major aims. 1) To complete in vitro studies of gammaretrovirus/HIV-1 pseudotyping; 2) To demonstrate gammaretrovirus/HIV-1 co-infections in local donors; 3) To demonstrate the effect of gammaretrovirus pseudotyping on vaginal transmission in an animal model; 4) To determine the prevalence of gammaretrovirus infection and HIV-1 co-infection in southern Africa. Natural pseudotyping of HIV-1 is predicted to occur in individuals co-infected with HIV-1 and a gammaretrovirus (xmrv/MLV) since the cellular tropism of these two viruses overlap to include T cells. The formation of xmrv-pseudoptyped HIV-1 (HIV-1/gp70) (now with the cell tropism of xmrv) in blood or lymphoid tissue would result in HIV-1 infection of normally resistant cells in the urogenital tract. Prior or subsequent infection of these cells with xmrv would result in the release of HIV-1/gp70 into seminal fluid or vaginal secretions. The potential implications of natural pseudotyping of HIV-1 are profound.
Probably the 'risk of sexual intercourse' for someone with severe ME is quite low, or in my case a once in a life time event.Interesting to know though, for people who are more 'active'. Maybe we're infectious only for the first few weeks, before virus migrates to tissue and if you feel really Flu Like you'd probably not be romancing someone during this time when you think you 'cath' a really bad Flu.Who knows.
Question: Because Im wondering, Ive met a lot of other CFS patients who like me have high cholesterol. That just made me think: might there be a correlation? Dr. Mikovits: Yeah, and nobodys ever looked. Its certainly something that they could look at correlating. I cant think of a reason why. You might presume youd have less, if youre using it up for another purpose. Question: What about children?Dr. Mikovits: We do have a little bit of data on that because we have two children in a study who have a genetic disease of cholesterol. Its called Niemann-Picks Disease. Its also known as Childhood Alzheimers. And these kids, you know its a cholesterol metabolism disease where eventually your brain, youll eventually die of it because if you get too much cholesterol, it messes up your brain and everything. And those kids have been treated by James Hildreth in Nashville, Tennessee, at a small college... Hes using Cyclodextran and some of the cholesterol drugs. Hes actually an HIV drug developer, and the kids are showing some improvement when he modulates that pathway and stops the virus from entering or exiting the cell, so we dont know anything about XMRV. We just know what other viruses do, so he is having success, suggesting that there are some opportunities there. Question: Are you working with him?Dr. Mikovits: Yeah, were working with him as well. Thats why I didn't list all the collaborators in the United States. Were providing reagents and whatever intellectual knowledge we have, and whatever physical abilities and instruments we have, to these collaborative efforts as well.
Once infected, LNCaP cells produce XMRV continuously. We use chronically infected LNCaP cells with XMRV (a gift from Dr. James Hildreth [...])
HIV deadly 99% + HGRVs aerosolised =
Yeah, even if the slim and none offers to exercise my 'downstairs giggle place' increased by one, and I was well enough to do something about it, the guilt attached to the risks kinda cancels it back out.
big big LOL at 'downstairs giggle place'.
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