Author Topic: Patent for Diagnosis and treatment of diseases or disorders associated with xenotropic...  (Read 1457 times)

Val

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Apologies if this patent application from Judy, Vinny and the Ruscettis has been previously posted. 

http://www.freepatentsonline.com/y2011/0117056.html



Thegodofpleasure

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Quote from the patent application (under the sub-heading "detection"):

Quote
"CFS can be detected, diagnosed, monitored, or managed by detecting XMRV in a subject or a sample from a subject. As another example, MS, such as Atypical Multiple Sclerosis (Batianello, S., et al., Neurol. Sci. Suppl. 4, S356-S360, 2004; Phadke, J. G. et al., J. Neurology, Neurosurgery and Psychiatry 46, 414-420, 1983), can be detected, diagnosed, monitored, or managed by detecting XMRV in a subject or a sample from a subject. Atypical MS can be an MS in which no demyelination is detected by standard procedures such as MRI scanning. An XMRV-related disease can be a neural disease, such as, without limitation, an XMRV-related neural disease that is not generally recognized as a neuroimmune disease, such as, for example, XMRV-related bipolar disorder or a neurodegenerative disease such as XMRV-related Alzheimer's disease or XMRV-related Parkinson's disease."

These are very wide ranging claims re XMRV related disease detection and monitoring !

Thegodofpleasure

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They are now (unequivocally) saying that anti-retrovirals are an appropriate therapeutic treatment for XMRV infection:

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Therapeutic Methods

Also provided is a process of treating an XMRV-related neuroimmune disease or an XMRV-related lymphoma in a subject in need administration of a therapeutically effective amount of an anti-retroviral agent......................


An effective amount of an anti-retroviral agent described herein is generally that which can reduce or eliminate XMRV replication or reduce or eliminate signs or symptoms of a neuroimmune disease or a lymphoma. An anti-retroviral agent can be an anti-retroviral compound or pharmaceutical composition including an anti-retroviral compound. Examples of anti-retroviral agents that can be used to manage or treat an XMRV-related neuroimmune disease or an XMRV-related lymphoma include, but are not limited to, acyclovir, penciclovir (famciclovir), gancyclovir (ganciclovir), deoxyguanosine, foscarnet, idoxuridine, trifluorothymidine, vidarabine, sorivudine, zidovudine (AZT, ZVD, azidothyidine, e.g., Retrovir), didanosine (ddI, e.g., Videx and Videx EC), zalcitabine (ddC, dideoxycytidine, e.g., Hivid), lamivudine (3TC, e.g., Epivir), stavudine (d4T, e.g., Zerit and Zerit XR), abacavir (ABC, e.g., Ziagen), emtricitabine (FTC, e.g., Emtriva (formerly Coviracil)), entecavir (INN, e.g., Baraclude), apricitabine (ATC), tenofovir (tenofovir disoproxil fumarate, e.g., Viread), adefovir (bis-POM PMPA, e.g., Preveon and Hepsera), multinucleoside resistance A, multinucleoside resistance B, nevirapine (e.g., Viramune), delavirdine (e.g., Rescriptor), efavirenz (e.g., Sustiva and Stocrin), etravirine (e.g., Intelence), adefovir dipivoxil, indinavir, ritonavir (e.g., Norvir), saquinavir (e.g., Fortovase, Invirase), nelfinavir (e.g., Viracept), agenerase, lopinavir (e.g., Kaletra), atasanavir (e.g., Reyataz), fosamprenavir (e.g., Lexiva, Telzir), tipranavir (e.g., Aptivus), darunavir (e.g., Prezista), amprenavir, deoxycytosine triphosphate, lamivudine triphosphate, emticitabine triphosphate, adefovir diphosphate, penciclovir triphosphate, lobucavir triphosphate, amantadine, rimantadine, zanamivir and oseltamivir, raltegravir (e.g., Isentress), elvitegravir (e.g., GS 9137 or JTK-303), MK-2048, maraviroc (e.g., Celsentri), enfuvirtide (e.g., Fuzeon), TNX-355, PRO 140, BMS-488043, plerixafor, epigallocatechin gallate, vicriviroc, aplaviroc, b12 (an antibody against HIV found in some long-term nonprogressors), griffithsin, DCM205, bevirimat, and vivecon. For example, one or more of AZT and cidofovir can be used to manage or treat an XMRV-related neuroimmune disease or an XMRV-related lymphoma. As another example, an interferon (e.g., interferon-β) can be used to manage or treat an XMRV-related neuroimmune disease or an XMRV-related lymphoma.

A fairly comprehensive list !

Patricia

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Judy Mikovits and Sandra and Frank Ruscetti applied for a different patent a while back.

http://www.faqs.org/patents/app/20100167268

It was discussed here:  http://www.mecfsforums.com/index.php/topic,500.0.html
There may be times when we are powerless to prevent injustice. But let there never be a time when we fail to protest. --Revenge

Thegodofpleasure

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The 22 examples at the end of the patent provide a comprehensive roundup of the techniques that the WPI (& Ruscettis) have used / developed in order to make these discoveries ............... lots for Gerwyn and others to get their teeth into !

since

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They are now (unequivocally) saying that anti-retrovirals are an appropriate therapeutic treatment for XMRV infection:

Patenting a process does not mean much, and does not mean it will actually work.
Quality over quantity.

Thegodofpleasure

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Patenting a process does not mean much, and does not mean it will actually work.

Yes, but the fact that they are saying this so publicly, is significant.

If they didn't think it works, why bother ......... and risk all the flak in so doing ?

since

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If they didn't think it works, why bother

It is to protect their intellectual property not to recommend treatments to patients.
Quality over quantity.

anciendaze

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can you explain "intellectual property" to me since? (in particular as it pertains to the list of drugs they are claiming can be used to manage or treat.) thanks!...
I'm afraid this is where things get murky, because attorneys are involved. 

Patent applications cannot simply claim discoveries, there must be some basis to believe applications with practical utility will result.  (Though some very strange mental gymnastics may be required to make some valid patents useful for purposes other than filing lawsuits.) 

Because of this you cast a very broad net when you write an application likely to be challenged.  If all suggested applications fail to materialize, the patent will be denied, or be worthless.  They don't know that all these treatments will work, they are simply listing those which have some likelihood of becoming useful for treatment.  If any one pans out, they have priority on a patent claim with real value.  Should they overlook the application which becomes most useful, the patent may be valid, but not worth much when others are ready to argue about every aspect. 

Royalties on test kits for HIV run to something like $100M/year.  These amounts will cause sane people taking professional legal advice to do bizarre things. 

Tango

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It is the same as this one that we discovered a few months ago http://www.wipo.int/pctdb/en/wo.jsp?IA=US2010039208&DISPLAY=STATUS
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Oerganix

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can you explain "intellectual property" to me since? (in particular as it pertains to the list of drugs they are claiming can be used to manage or treat.) thanks!

(this "news" is already all over facebook/net - pretty big deal to patients clamoring for treatment options - and because this is coming from WPI)

It appears to be a patent application for a test for XMRV:
 "FIELD OF THE INVENTION The present invention generally relates to xenotrophic murine leukemia virus-related virus and detection thereof."
 
Would this be the new one said to "phosphoresce green" or the one they've been doing? They talk about antigens, so maybe it's the one they've been doing.
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Patricia

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That is what it looks like to me, guido.  This one includes Dr. Lombardi's name, though, and the last one did not.
There may be times when we are powerless to prevent injustice. But let there never be a time when we fail to protest. --Revenge